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The primary site of infection in the lungs, known as the "Ghon focus", is generally located in either the upper part of the lower lobe, or the lower part of the upper lobe.
Tuberculosis is classified as one of the granulomatous inflammatory diseases.
However, the difficult culture process for this slow-growing organism can take two to six weeks for blood or sputum culture.
Treatment of TB uses antibiotics to kill the bacteria.
Upon cure, affected areas are eventually replaced by scar tissue.In nature, the bacterium can grow only within the cells of a host organism, but M. Using histological stains on expectorated samples from phlegm (also called "sputum"), scientists can identify MTB under a microscope. Those at high risk thus include: people who inject illicit drugs, inhabitants and employees of locales where vulnerable people gather (e.g.Since MTB retains certain stains even after being treated with acidic solution, it is classified as an acid-fast bacillus. prisons and homeless shelters), medically underprivileged and resource-poor communities, high-risk ethnic minorities, children in close contact with high-risk category patients, and health-care providers serving these patients.The granuloma may prevent dissemination of the mycobacteria and provide a local environment for interaction of cells of the immune system.However, more recent evidence suggests that the bacteria use the granulomas to avoid destruction by the host's immune system.